ATRX F2113Sfs*9
Gene Variant Detail

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Gene ATRX
Variant F2113Sfs*9
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions ATRX F2113Sfs*9 indicates a shift in the reading frame starting at amino acid 2113 and terminating 9 residues downstream causing a premature truncation of the 2492 amino acid Atrx protein (UniProt.org). F2113Sfs*9 has been identified in the scientific literature (PMID: 21252315, PMID: 39707189, PMID: 37713468), but has not been biochemically characterized and therefore, its effect on Atrx protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance
Category Variants Paths

ATRX mutant ATRX F2113Sfs*9

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Transcript NM_000489.6
gDNA chrX:g.77558836_77558839delATAA
cDNA c.6338_6341delTTAT
Protein p.F2113Sfs*9
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000489 chrX:g.77558836_77558839delATAA c.6338_6341delTTAT p.F2113Sfs*9 RefSeq GRCh38/hg38
NM_000489.4 chrX:g.77558836_77558839delATAA c.6338_6341delTTAT p.F2113Sfs*9 RefSeq GRCh38/hg38
NM_000489.6 chrX:g.77558836_77558839delATAA c.6338_6341delTTAT p.F2113Sfs*9 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References