ATRX L192S
Gene Variant Detail

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Gene ATRX
Variant L192S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ATRX L192S lies within the ADD domain of the Atrx protein (UniProt.org). L192S has been identified in sequencing studies (PMID: 24755471), but has not been biochemically characterized and therefore, its effect on Atrx protein function is unknown (PubMed, Mar 2026).
Associated Drug Resistance
Category Variants Paths

ATRX mutant ATRX L192S

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Transcript NM_000489.6
gDNA chrX:g.77688837A>G
cDNA c.575T>C
Protein p.L192S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005262154.6 chrX:g.77688837A>G c.575T>C p.L192S RefSeq GRCh38/hg38
XM_005262154.5 chrX:g.77688837A>G c.575T>C p.L192S RefSeq GRCh38/hg38
NM_000489.4 chrX:g.77688837A>G c.575T>C p.L192S RefSeq GRCh38/hg38
XM_005262154 chrX:g.77688837A>G c.575T>C p.L192S RefSeq GRCh38/hg38
XM_006724668 chrX:g.77688837A>G c.575T>C p.L192S RefSeq GRCh38/hg38
NM_000489.6 chrX:g.77688837A>G c.575T>C p.L192S RefSeq GRCh38/hg38
XM_017029603 chrX:g.77684513_77684514delAGinsCT c.574_575delCTinsAG p.L192S RefSeq GRCh38/hg38
NM_000489 chrX:g.77688837A>G c.575T>C p.L192S RefSeq GRCh38/hg38
XM_006724668.3 chrX:g.77688837A>G c.575T>C p.L192S RefSeq GRCh38/hg38
XM_047442191.1 chrX:g.77688837A>G c.575T>C p.L192S RefSeq GRCh38/hg38
XM_006724668.4 chrX:g.77688837A>G c.575T>C p.L192S RefSeq GRCh38/hg38
XM_017029603.1 chrX:g.77684513_77684514delCTinsAG c.574_575delCTinsAG p.L192S RefSeq GRCh38/hg38

Filtering

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References