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Gene | JAK2 |
Variant | amp |
Impact List | none |
Protein Effect | no effect |
Gene Variant Descriptions | JAK2 amp indicates an increased number of copies of the JAK2 gene. However, the mechanism causing the increase is unspecified. |
Associated Drug Resistance | |
Category Variants Paths |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
JAK2 amp | triple-receptor negative breast cancer | sensitive | NVP-BSK805 | Preclinical - Pdx | Actionable | In a preclinical study, NVP-BSK805 inhibited tumor growth in triple-negative breast cancer patient-derived xenograft models harboring JAK2 amplification (PMID: 27075627). | 27075627 |
JAK2 amp | triple-receptor negative breast cancer | sensitive | NVP-BSK805 + Paclitaxel | Preclinical - Pdx | Actionable | In a preclinical study, NVP-BSK805 with Abraxane (paclitaxel) inhibited tumor growth in triple-negative breast cancer patient-derived xenograft models with JAK2 amplification (PMID: 27075627). | 27075627 |