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Gene | PTEN |
Variant | inact mut |
Impact List | unknown |
Protein Effect | loss of function |
Gene Variant Descriptions | PTEN inact mut indicates that this variant results in a loss of function of the Pten protein. However, the specific amino acid change has not been identified. |
Associated Drug Resistance | |
Category Variants Paths |
PTEN mutant PTEN inact mut |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
PTEN inact mut | loss of function | Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor PI3K Inhibitor (Pan) PIK3CB inhibitor |
BRAF mut PTEN inact mut | ||
PIK3CA wild-type PTEN inact mut | ||
PIK3CA D1029Y PTEN inact mut | ||
APC inact mut PTEN inact mut | ||
HRAS G13R PTEN inact mut |