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| Profile Name | APC inact mut PTEN inact mut |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| APC inact mut PTEN inact mut | colorectal cancer | sensitive | Dactolisib | Preclinical | Actionable | In a preclinical study, BEZ235 inhibited PI3K/mTOR signaling in tumors and increased survival in transgenic animal models of colorectal cancer driven by APC and PTEN inactivation (PMID: 26206338). | 26206338 | |
| APC inact mut PTEN inact mut | colorectal cancer | no benefit | Binimetinib | Preclinical | Actionable | In a preclinical study, Mektovi (binimetinib) reduced proliferation in tumors acutely but did not improve survival in transgenic animal models of colorectal cancer driven by APC and PTEN inactivation (PMID: 26206338). | 26206338 | |
| APC inact mut PTEN inact mut | colorectal cancer | no benefit | Binimetinib + Dactolisib | Preclinical | Actionable | In a preclinical study, combination of BEZ235 and Mektovi (binimetinib) did not improve survival compared to single agent in transgenic animal models of colorectal cancer driven by APC and PTEN inactivation (PMID: 26206338). | 26206338 |