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Gene MAP2K1
Variant V60M
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions MAP2K1 V60M does not lie within any known functional domains of the Map2k1 protein (UniProt.org). V60M confers a gain of function to the Map2k1 protein as demonstrated by increased Mek and Erk phosphorylation relative to wild-type Map2k1 (PMID: 26566875).
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 act mut MAP2K1 V60M

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Transcript NM_002755.4
gDNA chr15:g.66435124G>A
cDNA c.178G>A
Protein p.V60M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002755.3 chr15:g.66435124G>A c.178G>A p.V60M RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66435124G>A c.178G>A p.V60M RefSeq GRCh38/hg38
NM_002755 chr15:g.66435124G>A c.178G>A p.V60M RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66435124G>A c.178G>A p.V60M RefSeq GRCh38/hg38
XM_011521783 chr15:g.66435190G>A c.178G>A p.V60M RefSeq GRCh38/hg38
XM_017022412 chr15:g.66435190G>A c.178G>A p.V60M RefSeq GRCh38/hg38
XM_011521783.3 chr15:g.66435190G>A c.178G>A p.V60M RefSeq GRCh38/hg38
XM_017022412.1 chr15:g.66435190G>A c.178G>A p.V60M RefSeq GRCh38/hg38
NM_001411065.1 chr15:g.66435190G>A c.178G>A p.V60M RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66435124G>A c.178G>A p.V60M RefSeq GRCh38/hg38
XM_017022411 chr15:g.66435124G>A c.178G>A p.V60M RefSeq GRCh38/hg38
XM_011521783.4 chr15:g.66435190G>A c.178G>A p.V60M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries