MAP2K1 V60M
Gene Variant Detail

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Gene MAP2K1
Variant V60M
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions MAP2K1 V60M does not lie within any known functional domains of the Map2k1 protein (UniProt.org). V60M confers a gain of function to the Map2k1 protein as demonstrated by increased Mek and Erk phosphorylation relative to wild-type Map2k1 (PMID: 26566875).
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 act mut MAP2K1 V60M

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Transcript NM_002755.4
gDNA chr15:g.66435124G>A
cDNA c.178G>A
Protein p.V60M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002755.4 chr15:g.66435124G>A c.178G>A p.V60M RefSeq GRCh38/hg38
XM_011521783.3 chr15:g.66435190G>A c.178G>A p.V60M RefSeq GRCh38/hg38
XM_017022412 chr15:g.66435190G>A c.178G>A p.V60M RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66435124G>A c.178G>A p.V60M RefSeq GRCh38/hg38
XM_011521783.4 chr15:g.66435190G>A c.178G>A p.V60M RefSeq GRCh38/hg38
NM_001411065.1 chr15:g.66435190G>A c.178G>A p.V60M RefSeq GRCh38/hg38
NM_002755 chr15:g.66435124G>A c.178G>A p.V60M RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66435124G>A c.178G>A p.V60M RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66435124G>A c.178G>A p.V60M RefSeq GRCh38/hg38
XM_017022412.1 chr15:g.66435190G>A c.178G>A p.V60M RefSeq GRCh38/hg38
XM_017022411 chr15:g.66435124G>A c.178G>A p.V60M RefSeq GRCh38/hg38
XM_011521783 chr15:g.66435190G>A c.178G>A p.V60M RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References