TP53 D259Y
Gene Variant Detail

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Gene TP53
Variant D259Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 D259Y lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). D259Y has been identified in the scientific literature (PMID: 30139768, PMID: 35724546, PMID: 38219954), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 D259Y

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Transcript NM_000546.6
gDNA chr17:g.7674188C>A
cDNA c.775G>T
Protein p.D259Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126115 chr17:g.7669620C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_001126115.1 chr17:g.7669620C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_001126115.2 chr17:g.7669620C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_000546 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674188C>A c.775G>T p.D259Y RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 D259Y melanoma sensitive LY3009120 Preclinical Actionable In a preclinical study, LY3009120 modestly inhibited soft agar growth of human melanoma cancer cells harboring TP53 D259Y in culture (PMID: 26343583). 26343583
TP53 D259Y melanoma sensitive Selumetinib Preclinical Actionable In a preclinical study, Koselugo (selumetinib) inhibited proliferation of human melanoma cells harboring TP53 D259Y in culture (PMID: 26343583). 26343583
TP53 D259Y melanoma sensitive Vemurafenib Preclinical Actionable In a preclinical study, Zelboraf (vemurafenib) inhibited proliferation of human melanoma cells TP53 D259Y in culture (PMID: 26343583). 26343583