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Gene BRAF
Variant A728V
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions BRAF A728V (also referred to as A727V) does not lie within any known functional domains of the Braf protein (UniProt.org). A728V results in an intermediate increase in Braf kinase activity compared to wild-type Braf and increased Erk phosphorylation in cell culture (PMID: 15035987).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF A728V

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Transcript NM_004333.6
gDNA chr7:g.140734715G>A
cDNA c.2183C>T
Protein p.A728V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378471.1 chr7:g.140726504G>A c.2183C>T p.A728V RefSeq GRCh38/hg38
NM_004333 chr7:g.140734715G>A c.2183C>T p.A728V RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140734715G>A c.2183C>T p.A728V RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140739876G>A c.2183C>T p.A728V RefSeq GRCh38/hg38
XM_017012558 chr7:g.140739876G>A c.2183C>T p.A728V RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140739876G>A c.2183C>T p.A728V RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140739876G>A c.2183C>T p.A728V RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140734715G>A c.2183C>T p.A728V RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140734715G>A c.2183C>T p.A728V RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140739876G>A c.2183C>T p.A728V RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140739876G>A c.2183C>T p.A728V RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140734715G>A c.2183C>T p.A728V RefSeq GRCh38/hg38
XM_017012559 chr7:g.140739876G>A c.2183C>T p.A728V RefSeq GRCh38/hg38
XM_005250045 chr7:g.140734715G>A c.2183C>T p.A728V RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References