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Gene BRAF
Variant F468C
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions BRAF F468C (also referred to as F467C) lies within the protein kinase domain of the Braf protein (UniProt.org). F468C confers a gain of function to the Braf protein as demonstrated by increased Braf kinase activity and downstream Erk phosphorylation, activation of NFkappaB signaling in reporter assays, and transformation of cultured cells (PMID: 15150094).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF F468C

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Transcript NM_004333.6
gDNA chr7:g.140781605A>C
cDNA c.1403T>G
Protein p.F468C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378468.1 chr7:g.140781605A>C c.1403T>G p.F468C RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781605A>C c.1403T>G p.F468C RefSeq GRCh38/hg38
NM_004333 chr7:g.140781605A>C c.1403T>G p.F468C RefSeq GRCh38/hg38
XM_005250045 chr7:g.140781605A>C c.1403T>G p.F468C RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140781605A>C c.1403T>G p.F468C RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781605A>C c.1403T>G p.F468C RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140781605A>C c.1403T>G p.F468C RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140781605A>C c.1403T>G p.F468C RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781605A>C c.1403T>G p.F468C RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries