Gene Variant Detail

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Gene BRAF
Variant N581D
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF N581D lies within the protein kinase domain of the Braf protein (UniProt.org). N581D results in transactivation of ELK at comparable levels to wild-type Braf in a reporter assay (PMID: 16474404), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF N581X BRAF N581D

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Transcript NM_004333.6
gDNA chr7:g.140754187T>C
cDNA c.1741A>G
Protein p.N581D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140754187T>C c.1741A>G p.N581D RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140754187T>C c.1741A>G p.N581D RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140754187T>C c.1741A>G p.N581D RefSeq GRCh38/hg38
XM_005250045 chr7:g.140754187T>C c.1741A>G p.N581D RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140754187T>C c.1741A>G p.N581D RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140754187T>C c.1741A>G p.N581D RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140754187T>C c.1741A>G p.N581D RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140754187T>C c.1741A>G p.N581D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF N581D lung non-small cell carcinoma predicted - sensitive RMC-4550 Preclinical - Pdx Actionable In a preclinical study, RMC-4550 treatment resulted in dose-dependent tumor growth inhibition in patient-derived xenograft (PDX) models of non-small cell lung cancer harboring BRAF N581D (PMID: 30104724). 30104724