Gene Variant Detail

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Gene BRAF
Variant N581Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF N581Y lies within the protein kinase domain of the Braf protein (UniProt.org). N581Y results in increased cell viability in culture (PMID: 32540409), but has not been fully biochemically characterized and therefore, its effect on Braf protein function is unknown.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF N581X BRAF N581Y

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Transcript NM_004333.6
gDNA chr7:g.140754187T>A
cDNA c.1741A>T
Protein p.N581Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005250045 chr7:g.140754187T>A c.1741A>T p.N581Y RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140754187T>A c.1741A>T p.N581Y RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140754187T>A c.1741A>T p.N581Y RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140754187T>A c.1741A>T p.N581Y RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140754187T>A c.1741A>T p.N581Y RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140754187T>A c.1741A>T p.N581Y RefSeq GRCh38/hg38
NM_004333 chr7:g.140754187T>A c.1741A>T p.N581Y RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140754187T>A c.1741A>T p.N581Y RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF N581Y colon cancer resistant GDC0879 Preclinical - Cell culture Actionable In a preclinical study, colon cancer cells harboring BRAF N581Y were resistant to GDC0879 induced growth inhibition in culture (PMID: 19276360). 19276360