Gene Variant Detail

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Gene BRAF
Variant T529I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF T529I is a gatekeeper mutation that lies within the protein kinase domain of the Braf protein (PMID: 20538618). T529I has been demonstrated to confer resistance to Raf inhibitors in the context of BRAF V600E (PMID: 20538618), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF T529I

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Transcript NM_004333.6
gDNA chr7:g.140777020G>A
cDNA c.1586C>T
Protein p.T529I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378474.1 chr7:g.140777020G>A c.1586C>T p.T529I RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140777020G>A c.1586C>T p.T529I RefSeq GRCh38/hg38
NM_004333 chr7:g.140777020G>A c.1586C>T p.T529I RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140777020G>A c.1586C>T p.T529I RefSeq GRCh38/hg38
XM_005250045 chr7:g.140777020G>A c.1586C>T p.T529I RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140777020G>A c.1586C>T p.T529I RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140777020G>A c.1586C>T p.T529I RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140777020G>A c.1586C>T p.T529I RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140777020G>A c.1586C>T p.T529I RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References