BRAF T529M
Gene Variant Detail

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Gene BRAF
Variant T529M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF T529M lies within the protein kinase domain of the Braf protein (UniProt.org). T529M has been demonstrated to confer resistance to Raf inhibitors (PMID: 20538618, PMID: 28783719, PMID: 31453322), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Jun 2025).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF T529M

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Transcript NM_004333.6
gDNA chr7:g.140777019_140777020delCCinsTG
cDNA c.1586_1587delCCinsTG
Protein p.T529M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378474.1 chr7:g.140777019_140777020delCCinsTG c.1586_1587delCCinsTG p.T529M RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140777019_140777020delCCinsTG c.1586_1587delCCinsTG p.T529M RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140777019_140777020delCCinsTG c.1586_1587delCCinsTG p.T529M RefSeq GRCh38/hg38
XM_005250045 chr7:g.140777019_140777020delGGinsCA c.1586_1587delCCinsTG p.T529M RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140777019_140777020delCCinsTG c.1586_1587delCCinsTG p.T529M RefSeq GRCh38/hg38
NM_004333 chr7:g.140777019_140777020delGGinsCA c.1586_1587delCCinsTG p.T529M RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140777019_140777020delCCinsTG c.1586_1587delCCinsTG p.T529M RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140777019_140777020delCCinsTG c.1586_1587delCCinsTG p.T529M RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140777019_140777020delCCinsTG c.1586_1587delCCinsTG p.T529M RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References