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Gene MAP2K1
Variant K97M
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions MAP2K1 K97M lies within the protein kinase domain of the Map2k1 protein (UniProt.org). K97M is referred to as a kinase dead variant and does not result in phosphorylation of Erk1/2 and therefore, confers a loss of function to the Map2k1 protein (PMID: 15342384).
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 inact mut MAP2K1 K97M

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Transcript NM_002755.4
gDNA chr15:g.66435236A>T
cDNA c.290A>T
Protein p.K97M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017022411.3 chr15:g.66435236A>T c.290A>T p.K97M RefSeq GRCh38/hg38
XM_017022411 chr15:g.66435236A>T c.290A>T p.K97M RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66435236A>T c.290A>T p.K97M RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66435236A>T c.290A>T p.K97M RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66435236A>T c.290A>T p.K97M RefSeq GRCh38/hg38
NM_002755 chr15:g.66435236A>T c.290A>T p.K97M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References