Gene Variant Detail

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Gene HRAS
Variant A146T
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions HRAS A146T lies within the SAK motif of the Hras protein (PMID: 24224811). A146T does not affect Hras intrinsic GTPase activity, but results in increased nucleotide exchange rates, which leads to increase GTP-bound Hras, activation of downstream signaling, and senescence of cultured cells (PMID: 24224811, PMID: 21850009).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS A146T

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Transcript NM_005343.4
gDNA chr11:g.533467C>T
cDNA c.436G>A
Protein p.A146T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_001130442 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_176795 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
HRAS A146T head and neck squamous cell carcinoma predicted - sensitive Tipifarnib Preclinical - Pdx Actionable In a preclinical study, a head and neck squamous cell carcinoma patient-derived xenograft (PDX) model harboring HRAS A146T was sensitive to treatment with Zarnestra (tipifarnib), demonstrating inhibition of tumor growth, decreased cell proliferation, and reduced Erk activity (PMID: 32727882). 32727882