ERBB3 V714M
Gene Variant Detail

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Gene ERBB3
Variant V714M
Impact List missense
Protein Effect no effect
Gene Variant Descriptions ERBB3 (HER3) V714M lies within the protein kinase domain of the Erbb3 (Her3) protein (UniProt.org). V714M demonstrates growth promotion and transforming ability in the presence of Erbb2 (Her2) similar to wild-type Erbb3 (Her3) in culture (PMID: 23680147).
Associated Drug Resistance
Category Variants Paths

ERBB3 mutant ERBB3 V714M

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Transcript NM_001982.4
gDNA chr12:g.56096587G>A
cDNA c.2140G>A
Protein p.V714M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001982.4 chr12:g.56096587G>A c.2140G>A p.V714M RefSeq GRCh38/hg38
NM_001982 chr12:g.56096587G>A c.2140G>A p.V714M RefSeq GRCh38/hg38
NM_001982.3 chr12:g.56096587G>A c.2140G>A p.V714M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB3 mutant invasive bladder transitional cell carcinoma predicted - sensitive Cisplatin + Gemcitabine + Sorafenib Phase II Actionable In a Phase II trial, ERBB3 mutations were only detected in patients with muscle-invasive urothelial bladder cancer that responded to Nexavar (sorafenib), Platinol (cisplatin) and Gemzar (gemcitabine) combination therapy (J Clin Oncol 35, 2017 (suppl 6S; abstract 345)). detail...
ERBB3 mutant Advanced Solid Tumor no benefit Neratinib Phase II Actionable In a Phase II trial (SUMMIT), Nerlynx (neratinib) treatment resulted in no objective response, a clinical benefit rate of 12.5% (2/16), and a median progression-free survival of 1.7 months in patients with advanced solid tumors harboring ERBB3 (HER3) mutations (PMID: 29420467; NCT01953926). 29420467