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Gene RET
Variant V915_K916insVHR
Impact List insertion
Protein Effect unknown
Gene Variant Descriptions RET V915_K916insVHR results in the insertion of three amino acids in the protein kinase domain of the Ret protein between amino acids 915 and 916 (UniProt.org). V915_K916insVHR has not been characterized in the scientific literature and therefore, its effect on Ret protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET V915_K916insVHR

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Transcript NM_020975.6
gDNA chr10:g.43121960_43121961insGTACATAGG
cDNA c.2745_2746insGTACATAGG
Protein p.V915_K916insVHR
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.6 chr10:g.43121960_43121961insGTACATAGG c.2745_2746insGTACATAGG p.V915_K916insVHR RefSeq GRCh38/hg38
NM_020630 chr10:g.43121960_43121961insGTACATAGG c.2745_2746insGTACATAGG p.V915_K916insVHR RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43121960_43121961insGTACATAGG c.2745_2746insGTACATAGG p.V915_K916insVHR RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43121960_43121961insGTACATAGG c.2745_2746insGTACATAGG p.V915_K916insVHR RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43121960_43121961insGTACATAGG c.2745_2746insGTACATAGG p.V915_K916insVHR RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43121960_43121961insGTACATAGG c.2745_2746insGTACATAGG p.V915_K916insVHR RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43121960_43121961insGTACATAGG c.2745_2746insGTACATAGG p.V915_K916insVHR RefSeq GRCh38/hg38
NM_020975 chr10:g.43121960_43121961insGTACATAGG c.2745_2746insGTACATAGG p.V915_K916insVHR RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43121960_43121961insGTACATAGG c.2745_2746insGTACATAGG p.V915_K916insVHR RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43121960_43121961insGTACATAGG c.2745_2746insGTACATAGG p.V915_K916insVHR RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References