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Gene ABL1
Variant R332W
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ABL1 R332W (corresponding to R351W in isoform IB) lies within the protein kinase domain of the Abl1 protein (UniProt.org). R332W results in increased Abl1 kinase activity, as demonstrated by modest increase in CRKL phosphorylation, and increased cytoplasmic retention of Abl1 in cell culture (PMID: 26758680).
Associated Drug Resistance
Category Variants Paths

ABL1 mutant ABL1 act mut ABL1 R332W

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Transcript NM_005157.6
gDNA chr9:g.130872946C>T
cDNA c.994C>T
Protein p.R332W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005157.5 chr9:g.130872946C>T c.994C>T p.R332W RefSeq GRCh38/hg38
NM_005157 chr9:g.130872946C>T c.994C>T p.R332W RefSeq GRCh38/hg38
NM_005157.6 chr9:g.130872946C>T c.994C>T p.R332W RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ABL1 R332W gain of function
ABL1 T315I ABL1 R332W