RET D631_L633delinsE
Gene Variant Detail

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Gene RET
Variant D631_L633delinsE
Impact List indel
Protein Effect unknown
Gene Variant Descriptions RET D631_L633delinsE results in a deletion of three amino acids in the extracellular domain of the Ret protein from amino acids 631 to 633, combined with the insertion of a glutamic acid (E) at the same site (UniProt.org). D631_L633delinsE has been identified in the scientific literature (PMID: 27082517), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Aug 2025).
Associated Drug Resistance
Category Variants Paths

RET mutant RET D631_L633delinsE

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Transcript NM_020975.6
gDNA chr10:g.43114493_43114498delCGAGCT
cDNA c.1893_1898delCGAGCT
Protein p.D631_L633delinsE
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.6 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_020975 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_020630 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
RET D631_L633delinsE unknown