Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene RET
Variant D631_L633delinsE
Impact List indel
Protein Effect unknown
Gene Variant Descriptions RET D631_L633delinsE results in a deletion of three amino acids in the extracellular domain of the Ret protein from amino acids 631 to 633, combined with the insertion of one glutamic acid (E) at the same site (UniProt.org). D631_L633delinsE has been identified in the scientific literature (PMID: 27082517), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET D631_L633delinsE

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_020975.6
gDNA chr10:g.43114493_43114498delCGAGCT
cDNA c.1893_1898delCGAGCT
Protein p.D631_L633delinsE
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406744.1 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_020630 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38
NM_020975 chr10:g.43114493_43114498delCGAGCT c.1893_1898delCGAGCT p.D631_L633delinsE RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
RET D631_L633delinsE unknown