Gene Variant Detail

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Gene BRAF
Variant Q257H
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF Q257H lies within the phorbol-ester/DAG-type zinc finger domain of the Braf protein (UniProt.org). Q257H has been identified in sequencing studies (PMID: 28852190, PMID: 27147599), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Sep 2024).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF Q257X BRAF Q257H

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Transcript NM_004333.6
gDNA chr7:g.140801501C>A
cDNA c.771G>T
Protein p.Q257H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378468.1 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
XM_017012559 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
NM_004333 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
XM_017012558 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
XM_005250045 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140801501C>A c.771G>T p.Q257H RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References