Gene Variant Detail

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Gene BRAF
Variant A598_T599insARC
Impact List insertion
Protein Effect gain of function - predicted
Gene Variant Descriptions BRAF A598_T599insARC results in the insertion of three amino acids in the protein kinase domain of the Braf protein between amino acids 598 and 599 (UniProt.org). BRAF A598_T599insARC has not been characterized however, other insertions between A598 and T599 are activating (PMID: 16501605), and therefore, A598_T599insARC is predicted to lead to a gain of Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF A598_T599insARC

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Transcript NM_004333.6
gDNA chr7:g.140753341_140753342insCACCTTGCA
cDNA c.1794_1795insGCAAGGTGT
Protein p.A598_T599insARC
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378474.1 chr7:g.140753341_140753342insCACCTTGCA c.1794_1795insGCAAGGTGT p.A598_T599insARC RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753341_140753342insCACCTTGCA c.1794_1795insGCAAGGTGT p.A598_T599insARC RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753341_140753342insCACCTTGCA c.1794_1795insGCAAGGTGT p.A598_T599insARC RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753341_140753342insCACCTTGCA c.1794_1795insGCAAGGTGT p.A598_T599insARC RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753341_140753342insCACCTTGCA c.1794_1795insGCAAGGTGT p.A598_T599insARC RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753341_140753342insCACCTTGCA c.1794_1795insGCAAGGTGT p.A598_T599insARC RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753341_140753342insCACCTTGCA c.1794_1795insGCAAGGTGT p.A598_T599insARC RefSeq GRCh38/hg38
NM_004333 chr7:g.140753341_140753342insCACCTTGCA c.1794_1795insGCAAGGTGT p.A598_T599insARC RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries