BRAF A598_T599insARC
Gene Variant Detail

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Gene BRAF
Variant A598_T599insARC
Impact List insertion
Protein Effect unknown
Gene Variant Descriptions BRAF A598_T599insARC results in the insertion of three amino acids in the protein kinase domain of the Braf protein between amino acids 598 and 599 (UniProt.org). A598_T599insARC has not been characterized in the scientific literature and therefore, its effect on Braf protein function is unknown (Mar 2026).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF A598_T599insARC

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Transcript NM_004333.6
gDNA chr7:g.140753341_140753342insCACCTTGCA
cDNA c.1794_1795insGCAAGGTGT
Protein p.A598_T599insARC
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.5 chr7:g.140753341_140753342insCACCTTGCA c.1794_1795insGCAAGGTGT p.A598_T599insARC RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753341_140753342insCACCTTGCA c.1794_1795insGCAAGGTGT p.A598_T599insARC RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753341_140753342insCACCTTGCA c.1794_1795insGCAAGGTGT p.A598_T599insARC RefSeq GRCh38/hg38
NM_004333 chr7:g.140753341_140753342insCACCTTGCA c.1794_1795insGCAAGGTGT p.A598_T599insARC RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753341_140753342insCACCTTGCA c.1794_1795insGCAAGGTGT p.A598_T599insARC RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753341_140753342insCACCTTGCA c.1794_1795insGCAAGGTGT p.A598_T599insARC RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753341_140753342insCACCTTGCA c.1794_1795insGCAAGGTGT p.A598_T599insARC RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753341_140753342insCACCTTGCA c.1794_1795insGCAAGGTGT p.A598_T599insARC RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References