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Gene MAP2K1
Variant G128C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MAP2K1 G128C lies within the protein kinase domain of the Map2k1 protein (UniProt.org). G128C has been identified in sequencing studies (PMID: 30933438, PMID: 26960398), but has not been biochemically characterized and therefore, its effect on Map2k1 protein function is unknown (PubMed, Sep 2024).
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 G128C

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Transcript NM_002755.4
gDNA chr15:g.66436836G>T
cDNA c.382G>T
Protein p.G128C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017022412 chr15:g.66444665G>T c.382G>T p.G128C RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66436836G>T c.382G>T p.G128C RefSeq GRCh38/hg38
NM_002755 chr15:g.66436836G>T c.382G>T p.G128C RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66436836G>T c.382G>T p.G128C RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66436836G>T c.382G>T p.G128C RefSeq GRCh38/hg38
XM_017022411 chr15:g.66436836G>T c.382G>T p.G128C RefSeq GRCh38/hg38
XM_017022412.1 chr15:g.66444665G>T c.382G>T p.G128C RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66436836G>T c.382G>T p.G128C RefSeq GRCh38/hg38
NM_001411065.1 chr15:g.66444665G>T c.382G>T p.G128C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References