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Gene BRAF
Variant E586K
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions BRAF E586K (also reported as E585K) lies within the protein kinase domain of the Braf protein (UniProt.org). E586K results in increased Braf kinase activity, and activation of Mek and Erk in cell culture (PMID: 15035987, PMID: 22510884), and increases cell proliferation and viability compared to wild-type Braf in one of two cell lines (PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF E586K

BRAF mutant BRAF E586X BRAF E586K

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Transcript NM_004333.6
gDNA chr7:g.140753379C>T
cDNA c.1756G>A
Protein p.E586K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378471.1 chr7:g.140749412C>T c.1756G>A p.E586K RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753379C>T c.1756G>A p.E586K RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753379C>T c.1756G>A p.E586K RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753379C>T c.1756G>A p.E586K RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753379C>T c.1756G>A p.E586K RefSeq GRCh38/hg38
NM_004333 chr7:g.140753379C>T c.1756G>A p.E586K RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753379C>T c.1756G>A p.E586K RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753379C>T c.1756G>A p.E586K RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753379C>T c.1756G>A p.E586K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References