BRAF E586K
Gene Variant Detail

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Gene BRAF
Variant E586K
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions BRAF E586K (also reported as E585K) lies within the protein kinase domain of the Braf protein (UniProt.org). E586K results in increased Braf kinase activity, and activation of Mek and Erk in cell culture (PMID: 15035987, PMID: 22510884), increases cell proliferation and viability compared to wild-type Braf in one of two cell lines (PMID: 29533785), and is associated with EGFR inhibitor resistance in the context of an EGFR exon 19 deletion and Braf V590I, G593V, and D594N (PMID: 38838224).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF E586K

BRAF mutant BRAF E586X BRAF E586K

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Transcript NM_004333.6
gDNA chr7:g.140753379C>T
cDNA c.1756G>A
Protein p.E586K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378474.1 chr7:g.140753379C>T c.1756G>A p.E586K RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753379C>T c.1756G>A p.E586K RefSeq GRCh38/hg38
NM_004333 chr7:g.140753379C>T c.1756G>A p.E586K RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140749412C>T c.1756G>A p.E586K RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753379C>T c.1756G>A p.E586K RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753379C>T c.1756G>A p.E586K RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753379C>T c.1756G>A p.E586K RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753379C>T c.1756G>A p.E586K RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753379C>T c.1756G>A p.E586K RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03843775 Phase Ib/II Binimetinib + Encorafenib A Study of Binimetinib and Encorafenib in Advanced BRAF Mutant Cancers Completed USA 0