CSF1R Y969F
Gene Variant Detail

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Gene CSF1R
Variant Y969F
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions CSF1R Y969F lies within the cytoplasmic domain of the Csf1r protein (UniProt.org). Y969F has not been biochemically characterized, but results in increased transforming ability compared to wild-type Csf1r protein in cell culture (PMID: 18971950) and therefore, is predicted to lead to a gain of Csf1r protein function.
Associated Drug Resistance
Category Variants Paths

CSF1R mutant CSF1R act mut CSF1R Y969F

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Transcript NM_001288705.3
gDNA chr5:g.150054082T>A
cDNA c.2906A>T
Protein p.Y969F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001349736.1 chr5:g.150054082T>A c.2906A>T p.Y969F RefSeq GRCh38/hg38
NM_005211 chr5:g.150054082T>A c.2906A>T p.Y969F RefSeq GRCh38/hg38
NM_005211.4 chr5:g.150054082T>A c.2906A>T p.Y969F RefSeq GRCh38/hg38
NM_005211.3 chr5:g.150054082T>A c.2906A>T p.Y969F RefSeq GRCh38/hg38
NM_001288705 chr5:g.150054082T>A c.2906A>T p.Y969F RefSeq GRCh38/hg38
NM_001288705.2 chr5:g.150054082T>A c.2906A>T p.Y969F RefSeq GRCh38/hg38
NM_001288705.3 chr5:g.150054082T>A c.2906A>T p.Y969F RefSeq GRCh38/hg38
NM_001349736.2 chr5:g.150054082T>A c.2906A>T p.Y969F RefSeq GRCh38/hg38
NM_001375320.1 chr5:g.150054082T>A c.2906A>T p.Y969F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References