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Gene RET
Variant E632_T636delinsSS
Impact List indel
Protein Effect unknown
Gene Variant Descriptions RET E632_T636delinsSS results in the deletion of five amino acids of the Ret protein from amino acids 632 to 636, combined with the insertion of two serines (S) at the same site (UniProt.org). E632_T636delinsSS results in increased transformation compared to wild-type in cell culture (PMID: 39095584), and therefore, is predicted to lead to gain of Ret protein function.
Associated Drug Resistance
Category Variants Paths

RET mutant RET E632_T636delinsSS

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Transcript NM_020975.6
gDNA chr10:g.43114494_43114508delinsAGCAGC
cDNA c.1894_1908delinsAGCAGC
Protein p.E632_T636delinsSS
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43114494_43114508delinsAGCAGC c.1894_1908delinsAGCAGC p.E632_T636delinsSS RefSeq GRCh38/hg38
NM_020630 chr10:g.43114494_43114508delinsAGCAGC c.1894_1908delinsAGCAGC p.E632_T636delinsSS RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114494_43114508delinsAGCAGC c.1894_1908delinsAGCAGC p.E632_T636delinsSS RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114494_43114508delinsAGCAGC c.1894_1908delinsAGCAGC p.E632_T636delinsSS RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114494_43114508delinsAGCAGC c.1894_1908delinsAGCAGC p.E632_T636delinsSS RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114494_43114508delinsAGCAGC c.1894_1908delinsAGCAGC p.E632_T636delinsSS RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114494_43114508delinsAGCAGC c.1894_1908delinsAGCAGC p.E632_T636delinsSS RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114494_43114508delinsAGCAGC c.1894_1908delinsAGCAGC p.E632_T636delinsSS RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114494_43114508delinsAGCAGC c.1894_1908delinsAGCAGC p.E632_T636delinsSS RefSeq GRCh38/hg38
NM_020975 chr10:g.43114494_43114508delinsAGCAGC c.1894_1908delinsAGCAGC p.E632_T636delinsSS RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries