RET Y606C - Gene Variant Detail

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Gene RET
Variant Y606C
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET Y606C lies within the extracellular domain of the Ret protein (UniProt.org). Y606C results in ligand independent dimerization and constitutive phosphorylation of Ret, increased Erk2 phosphorylation (PMID: 18248647, PMID: 36166639), and transformation in culture (PMID: 36166639).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET Y606C

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Transcript NM_020975.6
gDNA chr10:g.43113613A>G
cDNA c.1817A>G
Protein p.Y606C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43113613A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43113613A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43113613A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_001406773.1 chr10:g.43116702A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_001406781.1 chr10:g.43120187A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43113613A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_001406780.1 chr10:g.43120187A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_020630 chr10:g.43113613A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_020975 chr10:g.43113613A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43113613A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113613A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43113613A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43113613A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43113613A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_001406779.1 chr10:g.43120187A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_001406782.1 chr10:g.43120187A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43113613A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43116702A>G c.1817A>G p.Y606C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References