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Gene PIK3CA
Variant E545K
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA E545K is a hotspot mutation that lies within the PIK helical domain of the Pik3ca protein (UniProt.org). E545K results in increased phosphorylation of Akt and Mek1/2, growth factor-independent cell survival, and is transforming in culture (PMID: 26627007, PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA E545K

PIK3CA mutant PIK3CA exon10 PIK3CA E545X PIK3CA E545K

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Transcript NM_006218.4
gDNA chr3:g.179218303G>A
cDNA c.1633G>A
Protein p.E545K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.5 chr3:g.179218303G>A c.1633G>A p.E545K RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179218303G>A c.1633G>A p.E545K RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179218303G>A c.1633G>A p.E545K RefSeq GRCh38/hg38
NM_006218 chr3:g.179218303G>A c.1633G>A p.E545K RefSeq GRCh38/hg38
XM_011512894 chr3:g.179218303G>A c.1633G>A p.E545K RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179218303G>A c.1633G>A p.E545K RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179218303G>A c.1633G>A p.E545K RefSeq GRCh38/hg38
XM_006713658 chr3:g.179218303G>A c.1633G>A p.E545K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
PIK3CA E545K gain of function Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor mTOR Inhibitor mTORC1 Inhibitor mTORC2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor
BRAF G596R PIK3CA E545K
PIK3CA E545K PTEN loss
PIK3CA E545K PIK3CA amp
CDKN2A loss PIK3CA E545K PIK3CA amp
NRAS mut PIK3CA E545K
ROS1 rearrange PIK3CA E545K
PIK3CA E545K PIK3CA E726K
PIK3CA E545K PIK3CA M1043L
BRAF V600E PIK3CA E545K
PIK3CA L10_P18del PIK3CA E545K
NRAS G13R PIK3CA E545K
NRAS Q61K PIK3CA E545K
NRAS Q61L PIK3CA E545K
FGFR3 S249C PIK3CA E545K
FGFR3 S249C FGFR3 N540K PIK3CA E545K
HRAS G13V PIK3CA E545K
PIK3CA E545K PIK3CA W780R
PIK3CA E545K PIK3CA Q859H
PIK3CA E545K PIK3CA I817F
PIK3CA E545K PIK3CA H1047R