Molecular Profile Detail

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Profile Name PIK3CA L10_P18del PIK3CA E545K
Gene Variant Detail

PIK3CA E545K (gain of function)

PIK3CA L10_P18del (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA L10_P18del PIK3CA E545K gastrointestinal stromal tumor predicted - sensitive Alpelisib Case Reports/Case Series Actionable In a clinical case study, Piqray (alpelisib) treatment resulted in symptom improvement and stable disease maintained for more than 12 months in an adolescent patient with SDH-deficient gastrointestinal stromal tumor (GIST) harboring PIK3CA E545K and PIK3CA L10_P18del (PMID: 35917491). 35917491