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| Gene | CDKN2A |
| Variant | negative |
| Impact List | unknown |
| Protein Effect | loss of function |
| Gene Variant Descriptions | CDKN2A negative indicates a lack of expression of the CDKN2A mRNA and/or protein. |
| Associated Drug Resistance | |
| Category Variants Paths |
CDKN2A mutant CDKN2A inact mut CDKN2A negative |
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04681469 | Phase II | Dostarlimab-gxly + Niraparib | Induction and Maintenance Treatment With PARP Inhibitor and Immunotherapy in HPV-negative HNSCC (PRIME) | Recruiting | ITA | 0 |
| NCT03389477 | Phase II | Cisplatin + Palbociclib Cetuximab + Palbociclib | Los Tres Paso: Neoadjuvant Palbociclib Monotherapy, Concurrent Chemoradiation Therapy, Adjuvant Palbociclib Monotherapy in Patients With p16INK4a Negative, HPV-Unrelated Head and Neck Squamous Cell Carcinoma | Active, not recruiting | USA | 0 |
| NCT04247282 | Phase Ib/II | Bintrafusp alfa Bintrafusp alfa + ETBX-011 + ETBX-051 + ETBX-061 Bintrafusp alfa + ETBX-011 + ETBX-051 + ETBX-061 + Nogapendekin alfa inbakicept | Anti-PD-L1/TGF-beta Trap (M7824) Alone and in Combination With TriAd Vaccine and N-803 for Resectable Head and Neck Squamous Cell Carcinoma Not Associated With Human Papillomavirus Infection | Completed | USA | 0 |