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Therapy Name	Bintrafusp alfa + ETBX-011 + ETBX-051 + ETBX-061 + Nogapendekin alfa inbakicept
Synonyms	ALT-803 + M7824 + TriAd vaccine
Therapy Description

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Bintrafusp alfa		MSB0011359C\|M7824	Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 129 TGFBR2 Antibody 3	Bintrafusp alfa is a human PD-L1 (CD274) antibody fused with transforming growth factor-beta (TGF-beta, TGFBR2) receptor II extracellular domain, which blocks two immuno-inhibitory pathways simultaneously, therefore enhances anti-tumor immunity (PMID: 29298798, PMID: 32461347).
ETBX-011		ETBX 011\|ETBX011		ETBX-011 is an engineered adenoviral vaccine encoding human carcinoembryonic antigen that may stimulate anti-tumor immunity (Journal of Clinical Oncology 32, no. 15_suppl (May 2014) 3093-3093, PMID: 31594913).
ETBX-051		ETBX051\|ETBX 051		ETBX-051 is a virally based vaccine that infects cells and induces expression of the brachyury protein protein, which may activate the immune system to elicit a cytotoxic T-lymphocyte (CTL) response against brachyury expressing tumor cells (PMID: 31594913).
ETBX-061		ETBX061\|ETBX 061		ETBX-061 is a virally based vaccine that infects cells and causes expression of the Muc1 protein, which may activate the immune system to elicit a cytotoxic T-lymphocyte (CTL) response against Muc1 expressing tumor cells (PMID: 31594913).
Nogapendekin alfa inbakicept	Anktiva	N-803\|N803\|N 803\|nogapendekin alfa\|ALT803\|ALT 803\|ALT-803		Anktiva (nogapendekin alfa inbakicept) is a fusion protein comprising a mutant version of IL-15 with increased activity and IL-15Ra fused to the Fc region of IgG1, which activates CD8+ T-cells and promotes effector activity, potentially resulting in increased antitumor immune response (PMID: 24404427, PMID: 31338557). Anktiva (nogapendekin alfa inbakicept) in combination with BCG is FDA approved for use in patients with BCG-unresponsive non-muscle invasive bladder cancer with carcinoma in situ with or without papillary tumors (FDA.gov).

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT04247282	Phase Ib/II	Bintrafusp alfa Bintrafusp alfa + ETBX-011 + ETBX-051 + ETBX-061 Bintrafusp alfa + ETBX-011 + ETBX-051 + ETBX-061 + Nogapendekin alfa inbakicept	Anti-PD-L1/TGF-beta Trap (M7824) Alone and in Combination With TriAd Vaccine and N-803 for Resectable Head and Neck Squamous Cell Carcinoma Not Associated With Human Papillomavirus Infection	Completed	USA	0

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