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RET V292M - Gene Variant Detail

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Gene RET
Variant V292M
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET V292M lies within the cadherin-like domain 3 of the Ret protein (PMID: 20039896). V292M results in Ret autophosphorylation, increased phosphorylation of Mapk, Mek, and Shc, increased cell proliferation, but has low transforming activity in culture (PMID: 20039896).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET V292M

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Transcript NM_020975.6
gDNA chr10:g.43106382G>A
cDNA c.874G>A
Protein p.V292M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630 chr10:g.43106382G>A c.874G>A p.V292M RefSeq GRCh38/hg38
NM_001406779.1 chr10:g.43113567_43113569delGTTinsATG c.874_876delGTTinsATG p.V292M RefSeq GRCh38/hg38
NM_001406782.1 chr10:g.43113567_43113569delGTTinsATG c.874_876delGTTinsATG p.V292M RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43106382G>A c.874G>A p.V292M RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43106382G>A c.874G>A p.V292M RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43106382G>A c.874G>A p.V292M RefSeq GRCh38/hg38
NM_001406766.1 chr10:g.43109129_43109131delGTCinsATG c.874_876delGTCinsATG p.V292M RefSeq GRCh38/hg38
NM_001406774.1 chr10:g.43111342G>A c.874G>A p.V292M RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43111255_43111257delGTCinsATG c.874_876delGTCinsATG p.V292M RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43106382G>A c.874G>A p.V292M RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43106382G>A c.874G>A p.V292M RefSeq GRCh38/hg38
NM_001406770.1 chr10:g.43109129_43109131delGTCinsATG c.874_876delGTCinsATG p.V292M RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43106382G>A c.874G>A p.V292M RefSeq GRCh38/hg38
NM_001406787.1 chr10:g.43113567_43113569delGTTinsATG c.874_876delGTTinsATG p.V292M RefSeq GRCh38/hg38
NM_020975 chr10:g.43106382G>A c.874G>A p.V292M RefSeq GRCh38/hg38
NM_001406767.1 chr10:g.43109129_43109131delGTCinsATG c.874_876delGTCinsATG p.V292M RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43106382G>A c.874G>A p.V292M RefSeq GRCh38/hg38
NM_001406781.1 chr10:g.43113567_43113569delGTTinsATG c.874_876delGTTinsATG p.V292M RefSeq GRCh38/hg38
NM_001406780.1 chr10:g.43113567_43113569delGTTinsATG c.874_876delGTTinsATG p.V292M RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43106382G>A c.874G>A p.V292M RefSeq GRCh38/hg38
NM_001406773.1 chr10:g.43111255_43111257delGTCinsATG c.874_876delGTCinsATG p.V292M RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43106382G>A c.874G>A p.V292M RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43106382G>A c.874G>A p.V292M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References