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Gene MAP2K1
Variant L115A
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions MAP2K1 L115A lies within the protein kinase domain of the Map2k1 protein (UniProt.org). L115A is predicted to confer a gain of function to the Map2k1 protein, as demonstrated by increased kinase activity in an in vitro assay (PMID: 12370306) and is also associated with decreased binding and partial response to Mek inhibitors (PMID: 12370306).
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 act mut MAP2K1 L115A

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Transcript NM_002755.4
gDNA chr15:g.66436797_66436798delCTinsGC
cDNA c.343_344delCTinsGC
Protein p.L115A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017022411.2 chr15:g.66436797_66436798delCTinsGC c.343_344delCTinsGC p.L115A RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66436797_66436798delCTinsGC c.343_344delCTinsGC p.L115A RefSeq GRCh38/hg38
XM_017022411 chr15:g.66436797_66436798delCTinsGC c.343_344delCTinsGC p.L115A RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66436797_66436798delCTinsGC c.343_344delCTinsGC p.L115A RefSeq GRCh38/hg38
NM_002755 chr15:g.66436797_66436798delCTinsGC c.343_344delCTinsGC p.L115A RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66436797_66436798delCTinsGC c.343_344delCTinsGC p.L115A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 L115A Advanced Solid Tumor decreased response CI-1040 Preclinical - Biochemical Actionable In a preclinical study, MAP2K1 L115A demonstrated decreased sensitivity to CI-1040 (PD184352) in an in vitro kinase assay (PMID: 12370306). 12370306