RET C515S
Gene Variant Detail

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Gene RET
Variant C515S
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET C515S lies within the extracellular domain of the Ret protein (UniProt.org). C515S results in increased cell proliferation, Ret autophosphorylation in vitro and in vivo, and ligand-independent Ret homodimer formation (PMID: 18631007).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET C515S

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Transcript NM_020975.6
gDNA chr10:g.43112119T>A
cDNA c.1543T>A
Protein p.C515S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406767.1 chr10:g.43113627T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_020630 chr10:g.43112119T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43112119T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_001406766.1 chr10:g.43113627T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_001406770.1 chr10:g.43113627T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43112119T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43112119T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43112119T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43112119T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_001406761.1 chr10:g.43112876T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43112119T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_020975 chr10:g.43112119T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43112119T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_001406764.1 chr10:g.43112876T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43112119T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43112119T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_001406768.1 chr10:g.43112876T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_001406762.1 chr10:g.43112876T>A c.1543T>A p.C515S RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43112119T>A c.1543T>A p.C515S RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References