Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Gene | RET |
| Variant | C611R |
| Impact List | missense |
| Protein Effect | unknown |
| Gene Variant Descriptions | RET C611R lies within the extracellular domain of the Ret protein (UniProt.org). C611R has been identified in the scientific literature (PMID: 39489747, PMID: 30446652, PMID: 25163725), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Aug 2025). |
| Associated Drug Resistance | |
| Category Variants Paths |
RET mutant RET C611X RET C611R |
| Transcript | NM_020975.6 |
| gDNA | chr10:g.43113627T>C |
| cDNA | c.1831T>C |
| Protein | p.C611R |
| Source Database | RefSeq |
| Genome Build | GRCh38/hg38 |
| Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
|---|---|---|---|---|---|
| NM_020975 | chr10:g.43113627T>C | c.1831T>C | p.C611R | RefSeq | GRCh38/hg38 |
| NM_001406760.1 | chr10:g.43113627T>C | c.1831T>C | p.C611R | RefSeq | GRCh38/hg38 |
| NM_020630.5 | chr10:g.43113627T>C | c.1831T>C | p.C611R | RefSeq | GRCh38/hg38 |
| NM_001406759.1 | chr10:g.43113627T>C | c.1831T>C | p.C611R | RefSeq | GRCh38/hg38 |
| NM_001406763.1 | chr10:g.43113627T>C | c.1831T>C | p.C611R | RefSeq | GRCh38/hg38 |
| NM_020975.5 | chr10:g.43113627T>C | c.1831T>C | p.C611R | RefSeq | GRCh38/hg38 |
| NM_001406743.1 | chr10:g.43113627T>C | c.1831T>C | p.C611R | RefSeq | GRCh38/hg38 |
| NM_020630 | chr10:g.43113627T>C | c.1831T>C | p.C611R | RefSeq | GRCh38/hg38 |
| NM_020975.6 | chr10:g.43113627T>C | c.1831T>C | p.C611R | RefSeq | GRCh38/hg38 |
| NM_001406765.1 | chr10:g.43113627T>C | c.1831T>C | p.C611R | RefSeq | GRCh38/hg38 |
| NM_020630.7 | chr10:g.43113627T>C | c.1831T>C | p.C611R | RefSeq | GRCh38/hg38 |
| NM_001406744.1 | chr10:g.43113627T>C | c.1831T>C | p.C611R | RefSeq | GRCh38/hg38 |
| Molecular Profile | Protein Effect | Treatment Approaches |
|---|---|---|
| RET C611R | unknown |