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RET C618S - Gene Variant Detail

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Gene RET
Variant C618S
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions RET C618S lies within the extracellular domain of the Ret protein (UniProt.org). C618S is transforming in cell culture (PMID: 9230192), and therefore, is predicted to lead to a gain of Ret protein function.
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET C618S

RET mutant RET C618X RET C618S

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Transcript NM_020975.6
gDNA chr10:g.43113648T>A
cDNA c.1852T>A
Protein p.C618S
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.