Gene Variant Detail

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Gene RET
Variant C620S
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions RET C620S lies within the extracellular domain of the Ret protein (UniProt.org). C620S is transforming in cell culture (PMID: 9230192), and therefore, is predicted to lead to a gain of Ret protein function.
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET C620S

RET mutant RET C620X RET C620S

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Transcript NM_020975.6
gDNA chr10:g.43113654T>A
cDNA c.1858T>A
Protein p.C620S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406743.1 chr10:g.43113654T>A c.1858T>A p.C620S RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43113654T>A c.1858T>A p.C620S RefSeq GRCh38/hg38
NM_020975 chr10:g.43113654T>A c.1858T>A p.C620S RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43113654T>A c.1858T>A p.C620S RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113654T>A c.1858T>A p.C620S RefSeq GRCh38/hg38
NM_020630 chr10:g.43113654T>A c.1858T>A p.C620S RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43113654T>A c.1858T>A p.C620S RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43113654T>A c.1858T>A p.C620S RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43113654T>A c.1858T>A p.C620S RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43113654T>A c.1858T>A p.C620S RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43113654T>A c.1858T>A p.C620S RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43113654T>A c.1858T>A p.C620S RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries