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Gene RET
Variant K666E
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET K666E lies within the cytoplasmic domain of the Ret protein (UniProt.org). K666E results in increased Erk1/2 phosphorylation and is transforming in culture (PMID: 21690267).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET K666E

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Transcript NM_020975.6
gDNA chr10:g.43114596A>G
cDNA c.1996A>G
Protein p.K666E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.7 chr10:g.43114596A>G c.1996A>G p.K666E RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114596A>G c.1996A>G p.K666E RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114596A>G c.1996A>G p.K666E RefSeq GRCh38/hg38
NM_001406782.1 chr10:g.43123762A>G c.1996A>G p.K666E RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114596A>G c.1996A>G p.K666E RefSeq GRCh38/hg38
NM_020630 chr10:g.43114596A>G c.1996A>G p.K666E RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114596A>G c.1996A>G p.K666E RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114596A>G c.1996A>G p.K666E RefSeq GRCh38/hg38
NM_001406780.1 chr10:g.43123762A>G c.1996A>G p.K666E RefSeq GRCh38/hg38
NM_001406779.1 chr10:g.43123762A>G c.1996A>G p.K666E RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114596A>G c.1996A>G p.K666E RefSeq GRCh38/hg38
NM_020975 chr10:g.43114596A>G c.1996A>G p.K666E RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114596A>G c.1996A>G p.K666E RefSeq GRCh38/hg38
NM_001406781.1 chr10:g.43123762A>G c.1996A>G p.K666E RefSeq GRCh38/hg38

Filtering

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References