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Gene RET
Variant R912P
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions RET R912P lies within the protein kinase domain of the Ret protein (UniProt.org). R912P results in activation of ligand-independent signaling as demonstrated by increased Mapk phosphorylation compared to wild-type Ret in culture (PMID: 29625052), and therefore, is predicted to lead to a gain of Ret protein function.
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET R912P

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Transcript NM_020975.6
gDNA chr10:g.43121950G>C
cDNA c.2735G>C
Protein p.R912P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43121950G>C c.2735G>C p.R912P RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43121950G>C c.2735G>C p.R912P RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43121950G>C c.2735G>C p.R912P RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43121950G>C c.2735G>C p.R912P RefSeq GRCh38/hg38
NM_020975 chr10:g.43121950G>C c.2735G>C p.R912P RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43121950G>C c.2735G>C p.R912P RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43121950G>C c.2735G>C p.R912P RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43121950G>C c.2735G>C p.R912P RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43121950G>C c.2735G>C p.R912P RefSeq GRCh38/hg38
NM_020630 chr10:g.43121950G>C c.2735G>C p.R912P RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
RET R912P gain of function - predicted RET Inhibitor