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Gene RET
Variant Y806E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET Y806E lies within the protein kinase domain of the Ret protein (UniProt.org). Y806E has been demonstrated to confer secondary drug resistance in the context of other RET activating mutations (PMID: 19029224), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET Y806E

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Transcript NM_020975.6
gDNA chr10:g.43119554_43119556delTACinsGAG
cDNA c.2416_2418delTACinsGAG
Protein p.Y806E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406743.1 chr10:g.43119554_43119556delTACinsGAG c.2416_2418delTACinsGAG p.Y806E RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43119554_43119556delTACinsGAG c.2416_2418delTACinsGAG p.Y806E RefSeq GRCh38/hg38
NM_001406773.1 chr10:g.43123723_43123725delTATinsGAG c.2416_2418delTATinsGAG p.Y806E RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43123723_43123725delTATinsGAG c.2416_2418delTATinsGAG p.Y806E RefSeq GRCh38/hg38
NM_001406774.1 chr10:g.43124884_43124886delTACinsGAG c.2416_2418delTACinsGAG p.Y806E RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43119554_43119556delTACinsGAG c.2416_2418delTACinsGAG p.Y806E RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43119554_43119556delTACinsGAG c.2416_2418delTACinsGAG p.Y806E RefSeq GRCh38/hg38
NM_020975 chr10:g.43119554_43119556delTACinsGAG c.2416_2418delTACinsGAG p.Y806E RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43119554_43119556delTACinsGAG c.2416_2418delTACinsGAG p.Y806E RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43119554_43119556delTACinsGAG c.2416_2418delTACinsGAG p.Y806E RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43119554_43119556delTACinsGAG c.2416_2418delTACinsGAG p.Y806E RefSeq GRCh38/hg38
NM_020630 chr10:g.43119554_43119556delTACinsGAG c.2416_2418delTACinsGAG p.Y806E RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43119554_43119556delTACinsGAG c.2416_2418delTACinsGAG p.Y806E RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References