RET Y806F
Gene Variant Detail

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Gene RET
Variant Y806F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET Y806F lies within the protein kinase domain of the Ret protein (UniProt.org). Y806F results in reduced autophosphorylation and transforming activity in the context of a constitutively active form of RET (PMID: 14711813), but has not been individually characterized and therefore, its effect on Ret protein function is unknown (PubMed, Aug 2025).
Associated Drug Resistance
Category Variants Paths

RET mutant RET Y806F

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Transcript NM_020975.6
gDNA chr10:g.43119555A>T
cDNA c.2417A>T
Protein p.Y806F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630 chr10:g.43119555A>T c.2417A>T p.Y806F RefSeq GRCh38/hg38
NM_001406773.1 chr10:g.43123724A>T c.2417A>T p.Y806F RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43119555A>T c.2417A>T p.Y806F RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43119555A>T c.2417A>T p.Y806F RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43123724A>T c.2417A>T p.Y806F RefSeq GRCh38/hg38
NM_001406774.1 chr10:g.43124885A>T c.2417A>T p.Y806F RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43119555A>T c.2417A>T p.Y806F RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43119555A>T c.2417A>T p.Y806F RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43119555A>T c.2417A>T p.Y806F RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43119555A>T c.2417A>T p.Y806F RefSeq GRCh38/hg38
NM_020975 chr10:g.43119555A>T c.2417A>T p.Y806F RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43119555A>T c.2417A>T p.Y806F RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43119555A>T c.2417A>T p.Y806F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References