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Gene BRAF
Variant G466R
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions BRAF G466R (also referred to as G465R) lies within the glycine-rich loop in the protein kinase domain of the Braf protein (PMID: 14681681). G466R results in impaired Braf kinase activity, but activates Erk signaling in cell culture (PMID: 15046639), and in one of two cell lines, G466R decreased cell proliferation and cell viability compared to wild-type Braf (PMID: 29533785), and therefore, is predicted to lead to a loss of Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF G466X BRAF G466R

BRAF mutant BRAF inact mut BRAF G466R

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Transcript NM_004333.6
gDNA chr7:g.140781612C>T
cDNA c.1396G>A
Protein p.G466R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047420769.1 chr7:g.140781612C>T c.1396G>A p.G466R RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140781612C>T c.1396G>A p.G466R RefSeq GRCh38/hg38
NM_001378472.1 chr7:g.140777054C>G c.1396G>C p.G466R RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781612C>T c.1396G>A p.G466R RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140778001C>T c.1396G>A p.G466R RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140781612C>T c.1396G>A p.G466R RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781612C>T c.1396G>A p.G466R RefSeq GRCh38/hg38
XM_047420766.1 chr7:g.140781576C>G c.1396G>C p.G466R RefSeq GRCh38/hg38
NM_001378473.1 chr7:g.140777054C>G c.1396G>C p.G466R RefSeq GRCh38/hg38
NM_004333 chr7:g.140781612C>T c.1396G>A p.G466R RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781612C>T c.1396G>A p.G466R RefSeq GRCh38/hg38
XM_005250045 chr7:g.140781612C>T c.1396G>A p.G466R RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781612C>T c.1396G>A p.G466R RefSeq GRCh38/hg38

Filtering

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References