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Gene ABL1
Variant V468F
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ABL1 V468F lies within the protein kinase domain of the Abl1 protein (UniProt.org). V468F has been demonstrated to confer resistance to allosteric Abl1 inhibitors (PMID: 28329763, PMID: 27890928) and results in increased kinase activity and transformation in cultured cells (PMID: 27890928).
Associated Drug Resistance Y
Category Variants Paths

ABL1 mutant ABL1 act mut ABL1 V468F

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Transcript NM_005157.6
gDNA chr9:g.130878546G>T
cDNA c.1402G>T
Protein p.V468F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005157.5 chr9:g.130878546G>T c.1402G>T p.V468F RefSeq GRCh38/hg38
NM_005157 chr9:g.130878546G>T c.1402G>T p.V468F RefSeq GRCh38/hg38
NM_005157.6 chr9:g.130878546G>T c.1402G>T p.V468F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ABL1 V468F gain of function