ABL1 P223S
Gene Variant Detail

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Gene ABL1
Variant P223S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ABL1 P223S does not lie within any known functional domains of the Abl1 protein (UniProt.org). P223S has been demonstrated to confer resistance to allosteric Abl1 inhibitors (PMID: 28329763), but has not been biochemically characterized and therefore, its effect on Abl1 protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance Y
Category Variants Paths

ABL1 mutant ABL1 P223S

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Transcript NM_005157.6
gDNA chr9:g.130862880C>T
cDNA c.667C>T
Protein p.P223S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005157 chr9:g.130862880C>T c.667C>T p.P223S RefSeq GRCh38/hg38
NM_005157.5 chr9:g.130862880C>T c.667C>T p.P223S RefSeq GRCh38/hg38
NM_005157.6 chr9:g.130862880C>T c.667C>T p.P223S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References