SMARCA4 inact mut
Gene Variant Detail

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Gene SMARCA4
Variant inact mut
Impact List unknown
Protein Effect loss of function
Gene Variant Descriptions SMARCA4 inact mut indicates that this variant results in a loss of function of the Smarca4 protein. However, the specific amino acid change has not been identified.
Associated Drug Resistance
Category Variants Paths

SMARCA4 mutant SMARCA4 inact mut

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No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03213665 Phase II Tazemetostat Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial) Completed USA 1
NCT04741438 Phase III Ipilimumab + Nivolumab Pazopanib Efficacy of the Combination of Nivolumab and Ipilimumab as a Treatment in Patients With Sarcoma of Rare Subtype (RAR-Immune) Unknown status FRA 0
NCT06682806 Phase II Pembrolizumab + PRT3789 A Study of PRT3789 in Combination With Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors With a SMARCA4 Mutation Active, not recruiting USA | ESP 0
NCT06561685 Phase I Carboplatin + LY4050784 + Pembrolizumab + Pemetrexed Disodium LY4050784 Cisplatin + LY4050784 + Pembrolizumab + Pemetrexed Disodium Carboplatin + LY4050784 + Nab-paclitaxel + Pembrolizumab Carboplatin + LY4050784 + Paclitaxel + Pembrolizumab LY4050784 + Pembrolizumab A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors Recruiting USA | ESP 1
NCT04779151 Phase II Dostarlimab-gxly + Niraparib Basket Trial Exploring the Efficacy and Safety of the Combination of Niraparib and Dostarlimab (NIRADO) Terminated FRA 0