Gene Variant Detail

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Gene BRAF
Variant W619R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF W619R lies within the protein kinase domain of the Braf protein (UniProt.org). W619R has been identified in the scientific literature (PMID: 16179870, PMID: 36579983), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Sep 2024).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF W619R

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Transcript NM_004333.6
gDNA chr7:g.140753280A>T
cDNA c.1855T>A
Protein p.W619R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.5 chr7:g.140753280A>T c.1855T>A p.W619R RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753280A>T c.1855T>A p.W619R RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753280A>T c.1855T>A p.W619R RefSeq GRCh38/hg38
NM_004333 chr7:g.140753280A>T c.1855T>A p.W619R RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753280A>T c.1855T>A p.W619R RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753280A>T c.1855T>A p.W619R RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753280A>T c.1855T>A p.W619R RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753280A>T c.1855T>A p.W619R RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References