RET I788N
Gene Variant Detail

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Gene RET
Variant I788N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET I788N lies within the protein kinase domain of the Ret protein (UniProt.org). I788N has been associated with drug resistance in the context of RET fusions (PMID: 28615362, PMID: 37743366), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET I788N

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Transcript NM_020975.6
gDNA chr10:g.43118451T>A
cDNA c.2363T>A
Protein p.I788N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_001406769.1 chr10:g.43121974T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_001406772.1 chr10:g.43121974T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_020975 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43118451T>A c.2363T>A p.I788N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries