NTRK1 act mut
Gene Variant Detail

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Gene NTRK1
Variant act mut
Impact List unknown
Protein Effect gain of function
Gene Variant Descriptions NTRK1 act mut indicates that this variant results in a gain of function in the Ntrk1 protein. However, the specific amino acid change has not been identified.
Associated Drug Resistance
Category Variants Paths

NTRK1 mutant NTRK1 act mut

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK1 act mut Advanced Solid Tumor predicted - sensitive Selitrectinib Preclinical Actionable In a preclinical study, a cell line oncogenic mouse model expressing a constitutively active NTRK1 mutation demonstrated decreased phosphorylation of Ntrk1 and inhibition of tumor growth when treated with Selitrectinib (LOXO-195) (PMID: 28578312). 28578312
NTRK1 act mut Advanced Solid Tumor predicted - sensitive Larotrectinib Preclinical Actionable In a preclinical study, a cell line oncogenic mouse model expressing a constitutively active NTRK1 mutation demonstrated decreased phosphorylation of Ntrk1 and inhibition of tumor growth when treated with Vitrakvi (larotrectinib) (PMID: 28578312). 28578312